kisslicertalk.com

I have exactly the same error as the OP except on a Mac running Sierra OS I get a failed to save XXXXX.ini for each Profile.

I too have checked all the permisisons and filenames and they are all OK.

This pretty much prevents me trying Kisslicer which is a shame as a friend uses it in prefeence to S3d and Cura and it produces great prints.

Hopefully Admin or Devs will eventaully read this and find a solution.

All i can say, it must be a local problem with your PC .
I have used it now on win7, win10 and a friend runs it on ubuntu , current version

..what about trying y different OS in a VM for that ?

I personally think it is a bug in the Slicer software.
The chances of adding anything Windoze related to my system are zero as I moved away from that nausea of that OS years ago and will never go back to it.